Psychotropic Medication Usage in Individuals with Fetal Alcohol Spectrum Disorders (FASD) and Psychiatric Co-morbidities in Canada

Main Article Content

Andrew J Wrath
Mansfield Mela
Thuy Le
Michael Durr
Andrea DesRoches
Shawn Nomani
Tara Anderson
Kathy Unsworth
Jocelynn Cook

Abstract

Background and objective
Individuals with Fetal Alcohol Spectrum Disorder (FASD) tend to be prescribed a high number of psychotropic medications to treat high rates of comorbid psychiatric disorders. A lack of guidance regarding best practices for prescribing psychotropic medications to individuals with FASD probably accounts for this reliance on polypharmacy. The objective of this study is to describe the types of medications prescribed to individuals with prenatal alcohol exposure, comparing rates between individuals diagnosed with FASD and individuals without FASD as well as how medications are prescribed based on age, sex, and comorbid psychiatric disorders.



Material and methods
Data were drawn from Canada’s national FASD database. This database includes information collected during an FASD assessment related to diagnostic outcomes, secondary challenges, and medical and mental health information. Descriptive statistics were calculated for four diagnostic groups (FASD with sentinel facial features [FASD + SFF], FASD without sentinel facial features [FASD - SFF], at risk for FASD [“at risk”], and no FASD). Group demographics were compared using Chi-Square, Fisher’s Exact Test, and ANOVA, as appropriate. Differences in the proportion of individuals between these four diagnostic groups were calculated using each of the following six classes of psychotropic medications—antipsychotics, antidepressants/anxiolytic, anticonvulsants/mood stabilizers, stimulants, melatonin, and others—using ANOVA. Considering just the individuals with FASD by combining the FASD + SFF and FASD - SFF groups, independent sample tests were used to compare differences in the proportion of males and females prescribed different medications. Chi-Square and Fisher’s Exact Test were used to compare the proportion of individuals using psychotropic medications, according to category, within the FASD group based on the presence or absence of 13 comorbid psychiatric disorders.


Results
The overall sample included 2349 participants (mean value = 18.1 years, SD = 10.3). The sample included 1453 participants with an FASD diagnosis (n = 218, FASD + SFF, mean = 23.7 years, SD = 15.8, and n = 1235, FASD - SFF, mean = 19.5 years, SD = 10.0 years) and 896 participants who were assessed but did not receive an FASD diagnosis (n = 653, no FASD, mean = 16.1 years and n = 261, “at risk” for FASD, mean = 12.2 years). The FASD groups had a significantly higher rates of anxiety disorders, depressive disorders, and the presence of at least one comorbid psychiatric disorder compared to the no FASD and the “at risk” groups. Both FASD groups had a higher proportion of individuals taking antipsychotic and antidepressant/anxiolytic medications compared to the no FASD and “at risk” groups. Females with FASD were more often prescribed antidepressants/anxiolytics compared to males with FASD, while males with FASD were more often prescribed stimulants than females with FASD. The prevalence of antidepressants/anxiolytics, stimulants, and melatonin use by individuals with FASD differed across the lifespan. The prevalence of the prescription of six medication categories was found to differ according to psychiatric disorder.


Conclusion
Compared to individuals assessed as not fulfilling criteria for FASD, those with FASD had higher rates of psychiatric disorders and were prescribed significantly more antidepressants/anxiolytics and antipsychotics. The class and rate of prescriptions may support efforts in devising treatment guidelines for a complex disorder with known high comorbidity such as FASD.

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How to Cite
Wrath, A., Mela, M., Le, T., Durr, M., DesRoches, A., Nomani, S., Anderson, T., Unsworth, K., & Cook, J. (2022). Psychotropic Medication Usage in Individuals with Fetal Alcohol Spectrum Disorders (FASD) and Psychiatric Co-morbidities in Canada. Journal of Fetal Alcohol Spectrum Disorder, 4(SP1), e70-e90. https://doi.org/10.22374/jfasd.v4iSP1.21
Section
Articles
Author Biographies

Andrew J Wrath, Canada FASD Research Network, Vancouver, BC, Canada; Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Canada FASD Research Network, Vancouver, BC, Canada;

Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Mansfield Mela, Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Thuy Le, Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Michael Durr, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

Andrea DesRoches, Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Shawn Nomani, Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada

Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada

Tara Anderson, Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Department of Psychiatry, College of Medicine, Royal University Hospital, Saskatoon, SK, Canada

Kathy Unsworth, Canada FASD Research Network, Vancouver, BC, Canada

Canada FASD Research Network, Vancouver, BC, Canada

Jocelynn Cook, Society of Obstetricians and Gynecologists of Canada, Ottawa, ON, Canada

Society of Obstetricians and Gynecologists of Canada, Ottawa, ON, Canada

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