Predictors of Alcohol Use Disorders in Argentinean Pregnant Women

Main Article Content

Mariana Beatriz López
Aldana Lichtenberger
Mariana Cremonte


women, ethanol, alcoholics, risk factors, pregnancy


Background and Objective

High prenatal alcohol exposure, such as that presented by women with an alcohol use disorder (AUD), is related to severe adverse consequences such as fetal alcohol syndrome. Since most research on this topic comes from English speaking countries and is scarce in the Argentina, the aim of this study was to identify risk factors of AUD in Argentinean pregnant women. Predictors explored here included drinking alcohol, the use of other substances, and their accompanying motivational and socio-cultural characteristics.


Material and Methods

A systematic probabilistic sample of 641 puerperal women from an Argentinean city were personally interviewed after giving birth. DSM-5 AUD was established through the International Composite Diagnostic Interview -CIDI-, socio-economic level with the Graffar-Méndez Castellano scale and socio-demographic and psycho-social variables through ad-hoc questions. We then estimated the prevalence of AUD among all women and current drinkers. To identify predictors of AUD we performed logistic regressions with AUD status (positive vs. negative) as the outcome; drinking and substance use variables (age of alcohol consumption onset, usual type of drink, tobacco use during pregnancy, any consumption of other illegal substances), family and living conditions (partner status, previous children, occupation-labor situation, education level, socioeconomic level) and age, the number of health checkups during pregnancy, and general attitude towards alcohol consumption while pregnant, as predictors.



The prevalence of AUD was 8%, and among current drinkers was 9.5%. The participants’ age, age of alcohol consumption onset, tobacco use during pregnancy, illegal substances use (ever), number of health checkups during pregnancy and general attitude towards alcohol consumption during pregnancy, showed a significant relationship with AUD. As age increased a positive diagnosis of AUD was less likely, while having started to drink before the age of 15 made it more likely. Moreover, if the woman had used tobacco during pregnancy, it was 147% more likely to meet AUD diagnostic criteria, and if she had ever used illegal substances, she was 381% more likely to have an AUD. Finally, a positive diagnosis of AUD was less likely among those who had a negative attitude towards alcohol consumption during pregnancy and among those who had more health checkups during pregnancy. Notwithstanding, in the general model, age, age of alcohol consumption onset and tobacco use during pregnancy were not significant as predictors, which suggests that their relationship with AUD is explained by factors common to the other variables of the model.



Urgent action is needed in the region to prevent prenatal drinking, and pregnant women with an AUD should be the focus of distinct efforts. Interventions should target younger women, those who consume or have consumed illegal substances and those who maintain a more permissive attitude towards alcohol consumption during pregnancy.


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1. World Health Organization. Guidelines for the identification and management of substance use and substance use disorders in pregnancy. Geneva, Switzerland: World Health Organization; 2014.
2. Kesmodel U, Wisborg K, Olsen, SF, et al. Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life. Am J Epidemiol 2002;155(4):305–12.
3. Henriksen TB, Hjollund NH, Jensen TK, et al. Alcohol consumption at the time of conception and spontaneous abortion. Am J Epidemiol 2004;160(7):661–-67.
4. Patra J, Bakker R, Irving H, et al. Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta‐analyses. BJOG 2011;118(12):1411–21.
5. Dörrie N, Föcker M, Freunscht I, et al. Fetal alcohol spectrum disorders. Eur Child Adolesc Psychiatr 2014;23(10):863–75.
6. Senturias Y, Asamoah A. Fetal alcohol spectrum disorders: guidance for recognition, diagnosis, differential diagnosis and referral. Curr Probl Pediatr Adolesc Health Care 2014;44(4):88–95.
7. Popova S, Lange S, Probst C, et al. Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis. Lancet Glob Health 2017;5(3):e290–99.
8. May PA, Gossage JP. Maternal risk factors for fetal alcohol spectrum disorders: not as simple as it might seem. Alcohol Res Health 2011;34(1):15.
9. Vesga-Lopez O, Blanco C, Keyes K, et al. Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatr 2008;65(7):805–15.
10. Grant BF, Stinson FS, Harford TC. Age at onset of alcohol use and DSM-IV alcohol abuse and dependence: a 12-year follow-up. J Subst Abuse 2001;13(4):493–504.
11. Jackson KM., O’Neill SE, Sher KJ. Characterizing Alcohol Dependence: Transitions During Young and Middle Adulthood. Exp Clin Psychopharmacol 2006;14(2):228–44.
12. Hasin DS, Stinson FS, Ogburn E, et al. Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Alcohol Abuse and Dependence in the United States. Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 2007;64(7):830–42.
13. Knopik VS, Heath AC, Madden PA, et al. Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors. Psychol Med 2004;34(8):1519–30
14. Sartor CE, Lynskey MT, Heath AC, et al. The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction 2007;102(2):216–25.
15. DeWit DJ, Adlaf EM, Offord DR, et al. Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatr 2000;157(5):745–50.
16. Grant BF, Dawson DA. Age at onset of alcohol use and its association with DSM-IV alcohol Abuse and Dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 1997;9:103–10.
17. Grucza RA, Bierut LJ. Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health 2006;29(3):172–78.
18. Madden PAF, Bucholz KK, Martin NG. et al. Smoking and the genetic contribution to alcohol dependence. Risk. Alcohol Res Health 2000;24(4):209–14.
19. Poikolainen K. Risk factors for alcohol Dependence: A case-control study. Alcohol Alcohol 2000;35(2):190–96.
20. Ohannessian CM, Hesselbrock VM. The influence of perceived social support on the relationship between family history of alcoholism and drinking behaviors. Addiction 1993;88(12):1651–58.
21. Caetano R, Ramisetty-Mikler S, Floyd LR, et al. The epidemiology of drinking among women of child-bearing age. Alcohol Clin Exp Res 2006;30(6):1023–30.
22. Organización Mundial de la Salud. Composite International Diagnostic Interview. Ginebra, Suiza: Organización Mundial de Salud; 1990.
23. Castellano HM, de Méndez MC. Sociedad y estratificación: Método Graffar-Méndez Castellano. Caracas, Venezuela: Fundacredesa; 1994.
24. López MB. Saber, valorar y actuar: relaciones entre información, actitudes y consumo de alcohol durante la gestación. Salud y drogas 2013;13(1):35–46.
25. Fleury MJ, Grenier G, Bamvita JM, et al. Predictors of alcohol and drug dependence. Can J Psychiatr 2014;59(4):203–12.
26. Sánchez MA, Garriga M, Zamora FJ, et al. Screening of alcohol use disorders in psychiatric outpatients: influence of gender, age, and psychiatric diagnosis. Adicciones 2017;0(0):885.
27. Jones TC, Modeste N, Anderson B, et al. Factors influencing the intention to quit drinking alcohol among African American/Black pregnant women. CJHP 2007;5(3):131–44
28. Jackson KM, Sher KJ, Wood PK. Prospective analysis of comorbidity: tobacco and alcohol use disorders. J Abnorm Psychol 2000;109(4):679–94.
29. Wicker AW. Attitudes versus actions: The relationship of verbal and overt behavioral responses to attitude objects. J Soc Issues 1969;25(4):41–78.
30. DeVido J, Bogunovic O, Weiss RD. Alcohol use disorders in pregnancy. Harv Rev Psychiatr 2015;23(2):112.